Product Data Sheet
LY 171859
Catalog No. A60144
LY 171859 is a selective D2 receptor agonist that also displays notable reductase activity. This compound demonstrates enzymatic function within the cytoplasm of various tissues, including liver, lung, and kidney, and exhibits significant reductase activity in both rat and human blood. The reduction process mediated by LY 171859 is NADPH-dependent, with an apparent Km of 14.8 μM, and specifically incorporates the A-side hydrogen of NADPH into the reaction product. Additionally, this compound's enzymatic activity is sensitive to inhibition by cyanide and thiol reagents, making it a useful tool for studying dopamine receptor signaling and associated metabolic pathways.
Chemical Information
| Catalog Num | A60144 |
|---|---|
| M. Wt | 298.29 |
| Formula | C17H14O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 89139-28-6 |
| Synonyms | |
| SMILES | O=C(C1=CC=CC(CC2OC3=CC=C(C=C3C2=O)OC)=C1)O |
Biological Activity
| Description | LY 171859 is a selective D2 receptor agonist that also displays notable reductase activity. This compound demonstrates enzymatic function within the cytoplasm of various tissues, including liver, lung, and kidney, and exhibits significant reductase activity in both rat and human blood. The reduction process mediated by LY 171859 is NADPH-dependent, with an apparent Km of 14.8 μM, and specifically incorporates the A-side hydrogen of NADPH into the reaction product. Additionally, this compound's enzymatic activity is sensitive to inhibition by cyanide and thiol reagents, making it a useful tool for studying dopamine receptor signaling and associated metabolic pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
