Product Data Sheet
Metopimazine-d6
Catalog No. A60179
Metopimazine-d6 is a deuterium-labeled derivative of Metopimazine, a phenothiazine compound that functions primarily as a selective antagonist of dopamine D2 receptors. It is characterized by its inability to penetrate the blood-brain barrier, making it effective in inhibiting dopamine activity in peripheral regions and the chemoreceptor trigger zone, thus reducing nausea and vomiting. Metopimazine is commonly utilized in the management of chemotherapy-induced nausea and vomiting, with minimal central nervous system effects owing to its limited brain access. This stable isotope compound is valuable for research applications involving pharmacokinetics and metabolic studies.
Chemical Information
| Catalog Num | A60179 |
|---|---|
| M. Wt | 451.64 |
| Formula | C22H21D6N3O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1215315-86-8 |
| Synonyms | EXP999-d6; RP9965-d6 |
| SMILES | C(C(C(N1CCC(C(N)=O)CC1)([2H])[2H])([2H])[2H])(N2C=3C(SC=4C2=CC=CC4)=CC=C(S(C)(=O)=O)C3)([2H])[2H] |
Biological Activity
| Description | Metopimazine-d6 is a deuterium-labeled derivative of Metopimazine, a phenothiazine compound that functions primarily as a selective antagonist of dopamine D2 receptors. It is characterized by its inability to penetrate the blood-brain barrier, making it effective in inhibiting dopamine activity in peripheral regions and the chemoreceptor trigger zone, thus reducing nausea and vomiting. Metopimazine is commonly utilized in the management of chemotherapy-induced nausea and vomiting, with minimal central nervous system effects owing to its limited brain access. This stable isotope compound is valuable for research applications involving pharmacokinetics and metabolic studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
