Product Data Sheet
PD-89211
Catalog No. A60184
PD-89211 is a selective antagonist of the dopamine D4 receptor, exhibiting a Ki value of 3.7 nM. It effectively reverses Quinpirole-induced [3H]thymidine uptake in CHOpro5 cells, with an IC50 of 2.1 nM. This compound plays a significant role in regulating dopamine and norepinephrine metabolism in the hippocampus, making it valuable for research into central nervous system disorders, including schizophrenia.
Chemical Information
| Catalog Num | A60184 |
|---|---|
| M. Wt | 356.85 |
| Formula | C19H21ClN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 444725-49-9 |
| Synonyms | |
| SMILES | OCC1=CC=C(N2CCN(CC3=NC4=CC=CC=C4N3)CC2)C=C1Cl |
Biological Activity
| Description | PD-89211 is a selective antagonist of the dopamine D4 receptor, exhibiting a Ki value of 3.7 nM. It effectively reverses Quinpirole-induced [3H]thymidine uptake in CHOpro5 cells, with an IC50 of 2.1 nM. This compound plays a significant role in regulating dopamine and norepinephrine metabolism in the hippocampus, making it valuable for research into central nervous system disorders, including schizophrenia. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
