Product Data Sheet
SAE-14
Catalog No. A60234
SAE-14 is a selective antagonist of GPR183, exhibiting an IC50 value of 28.5 nM. It effectively inhibits 7α, 25-OHC–induced calcium mobilization in HL-60 cells with an IC50 under 50 nM. SAE-14 has demonstrated potential in reversing allodynia in murine models, making it a valuable tool for research into pain mechanisms and immune regulation.
Chemical Information
| Catalog Num | A60234 |
|---|---|
| M. Wt | 364.36 |
| Formula | C19H19F3N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1241280-25-0 |
| Synonyms | GPR183 antagonist-1 |
| SMILES | O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3 |
Biological Activity
| Description | SAE-14 is a selective antagonist of GPR183, exhibiting an IC50 value of 28.5 nM. It effectively inhibits 7α, 25-OHC–induced calcium mobilization in HL-60 cells with an IC50 under 50 nM. SAE-14 has demonstrated potential in reversing allodynia in murine models, making it a valuable tool for research into pain mechanisms and immune regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
