Product Data Sheet
BQ-788
Catalog No. A60237
BQ-788 is a selective endothelin B (ETB) receptor antagonist, exhibiting a potent IC50 of 1.2 nM against endothelin-1 (ET-1) binding in human Girardi heart cells. It demonstrates limited inhibitory activity on ETA receptors in the human neuroblastoma SK-N-MC cell line, with an IC50 of 1300 nM. This compound is primarily utilized in research on cardiovascular and neurobiological systems, aimed at elucidating the role of ETB receptors in various physiological and pathological conditions.
Chemical Information
| Catalog Num | A60237 |
|---|---|
| M. Wt | 641.80 |
| Formula | C34H51N5O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 173326-37-9 |
| Synonyms | |
| SMILES | CCCC[C@H](C(O)=O)NC([C@@H](CC1=CN(C(OC)=O)C2=CC=CC=C12)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O |
Biological Activity
| Description | BQ-788 is a selective endothelin B (ETB) receptor antagonist, exhibiting a potent IC50 of 1.2 nM against endothelin-1 (ET-1) binding in human Girardi heart cells. It demonstrates limited inhibitory activity on ETA receptors in the human neuroblastoma SK-N-MC cell line, with an IC50 of 1300 nM. This compound is primarily utilized in research on cardiovascular and neurobiological systems, aimed at elucidating the role of ETB receptors in various physiological and pathological conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
