Product Data Sheet
J-104132
Catalog No. A60238
J-104132 is a potent, orally active dual antagonist of the ETA and ETB receptors, exhibiting a Ki of 0.034 nM for ETA and 0.104 nM for ETB receptors. It effectively inhibits Endothelin-1 (ET-1)-induced signaling and vascular contractions in vitro. In vivo studies demonstrate that J-104132 mitigates hypertension, vascular remodeling, and diabetic endothelial dysfunction through dual blockade of ETA and ETB receptors, making it valuable for research into diabetic vascular complications.
Chemical Information
| Catalog Num | A60238 |
|---|---|
| M. Wt | 531.60 |
| Formula | C31H33NO7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 198279-45-7 |
| Synonyms | |
| SMILES | O=C(O)[C@H]1[C@H](C(C(C[C@H](C)C(O)=O)=C2)=CC=C2OC)C3=NC(CCCC)=CC=C3[C@@H]1C4=CC=C5OCOC5=C4 |
Biological Activity
| Description | J-104132 is a potent, orally active dual antagonist of the ETA and ETB receptors, exhibiting a Ki of 0.034 nM for ETA and 0.104 nM for ETB receptors. It effectively inhibits Endothelin-1 (ET-1)-induced signaling and vascular contractions in vitro. In vivo studies demonstrate that J-104132 mitigates hypertension, vascular remodeling, and diabetic endothelial dysfunction through dual blockade of ETA and ETB receptors, making it valuable for research into diabetic vascular complications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
