Product Data Sheet
Ro 46-8443
Catalog No. A60244
Ro 46-8443 is a selective antagonist of the endothelin ETB receptor, exhibiting at least 100-fold selectivity for ETB over ETA receptors (IC50: 34-69 nM vs. 6800 nM). Its specificity allows for targeted investigations into ETB receptor-related biological mechanisms. This compound is valuable for research applications focused on cardiovascular effects, cell proliferation, and pathophysiological conditions related to endothelin signaling.
Chemical Information
| Catalog Num | A60244 |
|---|---|
| M. Wt | 609.69 |
| Formula | C31H35N3O8S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 175556-12-4 |
| Synonyms | |
| SMILES | O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC(C3=CC=C(OC)C=C3)=NC(OC[C@H](O)CO)=C2OC4=CC=CC=C4OC)=O |
Biological Activity
| Description | Ro 46-8443 is a selective antagonist of the endothelin ETB receptor, exhibiting at least 100-fold selectivity for ETB over ETA receptors (IC50: 34-69 nM vs. 6800 nM). Its specificity allows for targeted investigations into ETB receptor-related biological mechanisms. This compound is valuable for research applications focused on cardiovascular effects, cell proliferation, and pathophysiological conditions related to endothelin signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
