Product Data Sheet
Nebentan
Catalog No. A60246
Nebentan is a selective, orally active non-peptide antagonist of the endothelin ETA receptor. It demonstrates significant inhibitory activity against [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptors, with Ki values of 0.697 nM and 569 nM, respectively. Research indicates that Nebentan may effectively mitigate the progression of cor pulmonale and myocardial infarction in vivo, making it a valuable tool for studies related to cardiovascular and pulmonary diseases.
Chemical Information
| Catalog Num | A60246 |
|---|---|
| M. Wt | 491.52 |
| Formula | C24H21N5O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 403604-85-3 |
| Synonyms | YM598 free base |
| SMILES | O=S(/C=C/C1=CC=CC=C1)(NC2=NC(C3=NC=CC=N3)=NC(OC)=C2OC4=CC=CC=C4OC)=O |
Biological Activity
| Description | Nebentan is a selective, orally active non-peptide antagonist of the endothelin ETA receptor. It demonstrates significant inhibitory activity against [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptors, with Ki values of 0.697 nM and 569 nM, respectively. Research indicates that Nebentan may effectively mitigate the progression of cor pulmonale and myocardial infarction in vivo, making it a valuable tool for studies related to cardiovascular and pulmonary diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
