Product Data Sheet

Endothelin (16-21)

Catalog No. A60283

main product photo
Endothelin (16-21) functions as a selective agonist for the ETB receptor, exhibiting an EC50 of 228 nM in guinea-pig bronchus. This compound effectively induces smooth muscle contraction, making it a valuable tool for studying respiratory conditions such as asthma and cardiovascular diseases, including hypertension. Its targeted mechanism provides insights into ETB receptor signaling pathways relevant to these medical research applications.
Chemical Information
Catalog NumA60283
M. Wt795.92
FormulaC39H57N9O9
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.121377-67-1
Synonyms
SMILESC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)N)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=2C=3C(NC2)=CC=CC3
Biological Activity
DescriptionEndothelin (16-21) functions as a selective agonist for the ETB receptor, exhibiting an EC50 of 228 nM in guinea-pig bronchus. This compound effectively induces smooth muscle contraction, making it a valuable tool for studying respiratory conditions such as asthma and cardiovascular diseases, including hypertension. Its targeted mechanism provides insights into ETB receptor signaling pathways relevant to these medical research applications.
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