Product Data Sheet
FR139317
Catalog No. A60291
FR139317 is a selective antagonist of the endothelin A (ETA) receptor. This compound effectively inhibits cerebral activation induced by endothelin-1 in conscious rat models. Additionally, FR139317 demonstrates the capability to reduce cerebral vasospasm in canine subjects, highlighting its relevance in studies related to vascular regulation and cerebrovascular conditions.
Chemical Information
| Catalog Num | A60291 |
|---|---|
| M. Wt | 604.74 |
| Formula | C33H44N6O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 142375-60-8 |
| Synonyms | PD 147953 |
| SMILES | O=C(O)[C@@H](CC1=NC=CC=C1)NC([C@@H](CC2=CN(C)C3=CC=CC=C23)NC([C@H](CC(C)C)NC(N4CCCCCC4)=O)=O)=O |
Biological Activity
| Description | FR139317 is a selective antagonist of the endothelin A (ETA) receptor. This compound effectively inhibits cerebral activation induced by endothelin-1 in conscious rat models. Additionally, FR139317 demonstrates the capability to reduce cerebral vasospasm in canine subjects, highlighting its relevance in studies related to vascular regulation and cerebrovascular conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
