Product Data Sheet
WKYMVM-NH2
Catalog No. A60322
WKYMVM-NH2 is a hexapeptide that acts as an agonist for the FPRL1 and FPRL2 receptors, primarily activating neutrophils and myeloid cells. Its potent biological activity is characterized by EC50 values of 2 nM and 80 nM in HL-60 cells expressing FPRL1 and FPRL2, respectively. WKYMVM-NH2 induces chemotaxis in HL-60-FPRL2 cells, with optimal migration observed between 10 and 50 nM, and significantly stimulates superoxide production in neutrophils with an EC50 of 75 nM. This peptide serves as a valuable tool for studying inflammatory diseases and related mechanisms.
Chemical Information
| Catalog Num | A60322 |
|---|---|
| M. Wt | 856.11 |
| Formula | C41H61N9O7S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 187986-11-4 |
| Synonyms | |
| SMILES | C([C@@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)[C@@H](C)C)=O)CCSC)=O)=O)CCCCN)=O)N)C=2C=3C(NC2)=CC=CC3 |
Biological Activity
| Description | WKYMVM-NH2 is a hexapeptide that acts as an agonist for the FPRL1 and FPRL2 receptors, primarily activating neutrophils and myeloid cells. Its potent biological activity is characterized by EC50 values of 2 nM and 80 nM in HL-60 cells expressing FPRL1 and FPRL2, respectively. WKYMVM-NH2 induces chemotaxis in HL-60-FPRL2 cells, with optimal migration observed between 10 and 50 nM, and significantly stimulates superoxide production in neutrophils with an EC50 of 75 nM. This peptide serves as a valuable tool for studying inflammatory diseases and related mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
