Product Data Sheet
AP5 sodium
Catalog No. A60374
AP5 sodium is a selective GPR40 receptor agonist that functions as a positive allosteric modulator of endogenous ligands (AgoPAM). It exhibits potent biological activity, with EC50 values of 0.49 nM in rat models and 0.8 nM in human assays for inositol monophosphate (IP1) signaling. This compound holds potential for applications in type II diabetes research, contributing to the understanding of glucose metabolism and insulin secretion mechanisms.
Chemical Information
| Catalog Num | A60374 |
|---|---|
| M. Wt | 483.51 |
| Formula | C28H27FNNaO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1623143-67-8 |
| Synonyms | |
| SMILES | FC1=CC(C2=CC(OC)=NC=C2)=CC=C1[C@@H]3CCC(C=CC([C@H](C4CC4)[C@H](C)C(O[Na])=O)=C5)=C5O3 |
Biological Activity
| Description | AP5 sodium is a selective GPR40 receptor agonist that functions as a positive allosteric modulator of endogenous ligands (AgoPAM). It exhibits potent biological activity, with EC50 values of 0.49 nM in rat models and 0.8 nM in human assays for inositol monophosphate (IP1) signaling. This compound holds potential for applications in type II diabetes research, contributing to the understanding of glucose metabolism and insulin secretion mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
