Product Data Sheet
AM-3189
Catalog No. A60381
AM-3189 is a selective agonist of GPR40, with EC50 values of 33 nM in buffer and 10 μM in 100% human serum. This compound enhances glucose-stimulated insulin secretion from pancreatic β cells, offering potential therapeutic applications in type 2 diabetes research. Importantly, AM-3189 shows minimal activity on GPR41, GPR43, and PPAR subtypes, and exhibits low central nervous system penetration. Its efficacy in reducing blood glucose levels has been demonstrated in humanized GPR40 mouse models, making it a valuable tool for metabolic studies.
Chemical Information
| Catalog Num | A60381 |
|---|---|
| M. Wt | 460.95 |
| Formula | C27H25ClN2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 916219-50-6 |
| Synonyms | |
| SMILES | OC(C[C@H](C1=NC=CN1C)C2=CC=C(C=C2)OCC3=CC(C4=C(C=C(C=C4)Cl)C)=CC=C3)=O |
Biological Activity
| Description | AM-3189 is a selective agonist of GPR40, with EC50 values of 33 nM in buffer and 10 μM in 100% human serum. This compound enhances glucose-stimulated insulin secretion from pancreatic β cells, offering potential therapeutic applications in type 2 diabetes research. Importantly, AM-3189 shows minimal activity on GPR41, GPR43, and PPAR subtypes, and exhibits low central nervous system penetration. Its efficacy in reducing blood glucose levels has been demonstrated in humanized GPR40 mouse models, making it a valuable tool for metabolic studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
