Product Data Sheet
TC-G 1005
Catalog No. A60391
TC-G 1005 is a selective agonist of the Takeda G protein-coupled receptor 5 (TGR5), demonstrating potent activity with EC50 values of 0.72 nM for human TGR5 and 6.2 nM for mouse TGR5. This compound has been shown to effectively reduce glucose levels in vivo, making it a valuable tool for researching metabolic disorders and the role of TGR5 in glucose homeostasis. Its oral bioactivity supports its application in various pharmacological studies related to energy metabolism and diabetic therapies.
Chemical Information
| Catalog Num | A60391 |
|---|---|
| M. Wt | 399.48 |
| Formula | C25H25N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1415407-60-1 |
| Synonyms | |
| SMILES | O=C(C1=CN=CC=C1OC2=C(C=CC(C)=C2)C)N3C4=CC=CC=C4N(C5CC5)CC3 |
Biological Activity
| Description | TC-G 1005 is a selective agonist of the Takeda G protein-coupled receptor 5 (TGR5), demonstrating potent activity with EC50 values of 0.72 nM for human TGR5 and 6.2 nM for mouse TGR5. This compound has been shown to effectively reduce glucose levels in vivo, making it a valuable tool for researching metabolic disorders and the role of TGR5 in glucose homeostasis. Its oral bioactivity supports its application in various pharmacological studies related to energy metabolism and diabetic therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
