Product Data Sheet
RG-239
Catalog No. A60406
RG-239 is a selective TGR5 agonist with an EC50 of 120 nM, exhibiting superior potency compared to Betulinic acid (EC50 = 1.04 μM). It enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at elevated concentrations. Additionally, RG-239 effectively inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 macrophages and microglial cells. This compound is valuable for studies related to type 2 diabetes and neurodegenerative disorders.
Chemical Information
| Catalog Num | A60406 |
|---|---|
| M. Wt | 496.76 |
| Formula | C33H52O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1199222-56-4 |
| Synonyms | |
| SMILES | OC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@](O)(CC=C)CC5)C)([H])CC4)C)([H])CC3)C)C)=O |
Biological Activity
| Description | RG-239 is a selective TGR5 agonist with an EC50 of 120 nM, exhibiting superior potency compared to Betulinic acid (EC50 = 1.04 μM). It enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at elevated concentrations. Additionally, RG-239 effectively inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 macrophages and microglial cells. This compound is valuable for studies related to type 2 diabetes and neurodegenerative disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
