Product Data Sheet
5β-Cholestane-3α,7α,12α,25-tetrol
Catalog No. A60412
5β-Cholestane-3α,7α,12α,25-tetrol is a potent TGR5 activator, exhibiting an EC50 of 1.36 μM. This bile acid alcohol plays a significant role in regulating metabolic processes and has shown promising biological activity relevant to energy expenditure and glucose metabolism. Additionally, it serves as a crucial disease marker in Cerebrotendinous xanthomatosis (CTX), making it valuable for research into bile acid signaling and related metabolic disorders.
Chemical Information
| Catalog Num | A60412 |
|---|---|
| M. Wt | 436.67 |
| Formula | C27H48O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 18866-87-0 |
| Synonyms | 3α,7α,12α,25-Tetrahydroxycoprostane |
| SMILES | O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCCC(C)(O)C)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C |
Biological Activity
| Description | 5β-Cholestane-3α,7α,12α,25-tetrol is a potent TGR5 activator, exhibiting an EC50 of 1.36 μM. This bile acid alcohol plays a significant role in regulating metabolic processes and has shown promising biological activity relevant to energy expenditure and glucose metabolism. Additionally, it serves as a crucial disease marker in Cerebrotendinous xanthomatosis (CTX), making it valuable for research into bile acid signaling and related metabolic disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
