Product Data Sheet
Taspoglutide acetate
Catalog No. A60641
Taspoglutide acetate is a selective agonist of the glucagon-like peptide-1 receptor (GLP-1R), exhibiting a Ki value of 1.1 nM. This compound effectively stimulates cAMP accumulation in CHO-K1 cells expressing human GLP-1R, with an EC50 of 0.06 nM. In vivo studies demonstrate that Taspoglutide acetate significantly reduces blood glucose levels and elevates insulin levels in Zucker diabetic obese rats. Additionally, it has been shown to lower gastric inhibitory polypeptide (GIP) levels, plasma triglycerides, and body weight in this model, highlighting its potential for metabolic research and diabetes treatment.
Chemical Information
| Catalog Num | A60641 |
|---|---|
| M. Wt | 3339.71 (free base) |
| Formula | C152H232N40O45.xC2H4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1022150-16-8 |
| Synonyms | ITM077 acetate; R1583 acetate; BIM51077 acetate |
| SMILES | C(C)(O)=O.C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)(C)C)=O)CCCCN)=O)[C@H](C)C)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC(CNC([C@@H](NC(C(NC([C@H](CC4=CN=CN4)N)=O)(C)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)C(C)C)=O)CO)=O)CO)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCN)=O)CCC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)C=5C=6C(NC5)=CC=CC6 |
Biological Activity
| Description | Taspoglutide acetate is a selective agonist of the glucagon-like peptide-1 receptor (GLP-1R), exhibiting a Ki value of 1.1 nM. This compound effectively stimulates cAMP accumulation in CHO-K1 cells expressing human GLP-1R, with an EC50 of 0.06 nM. In vivo studies demonstrate that Taspoglutide acetate significantly reduces blood glucose levels and elevates insulin levels in Zucker diabetic obese rats. Additionally, it has been shown to lower gastric inhibitory polypeptide (GIP) levels, plasma triglycerides, and body weight in this model, highlighting its potential for metabolic research and diabetes treatment. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
