Product Data Sheet
AG-045572
Catalog No. A60696
AG-045572 is a potent antagonist of the gonadotropin-releasing hormone (GnRH) receptor, exhibiting Ki values of 6.0 nM for the human and 3.8 nM for the rat GnRH receptor. This compound is metabolized by CYP3A and effectively represses testosterone levels, making it valuable for research on reproductive hormone regulation and potential therapeutic applications in hormone-dependent conditions. Its specific activity highlights its relevance in pharmacological studies focusing on reproductive health and endocrine function.
Chemical Information
| Catalog Num | A60696 |
|---|---|
| M. Wt | 491.62 |
| Formula | C30H37NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 263847-55-8 |
| Synonyms | |
| SMILES | CC1(C2=CC(CC3=CC=C(C(NC4=C(C=C(OC)C=C4OC)OC)=O)O3)=C(C)C=C2C(C)(C)CC1)C |
Biological Activity
| Description | AG-045572 is a potent antagonist of the gonadotropin-releasing hormone (GnRH) receptor, exhibiting Ki values of 6.0 nM for the human and 3.8 nM for the rat GnRH receptor. This compound is metabolized by CYP3A and effectively represses testosterone levels, making it valuable for research on reproductive hormone regulation and potential therapeutic applications in hormone-dependent conditions. Its specific activity highlights its relevance in pharmacological studies focusing on reproductive health and endocrine function. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
