Product Data Sheet
ORG 30276
Catalog No. A60711
ORG 30276 is a potent GnRH receptor antagonist that effectively inhibits gonadotropin secretion by reducing serum LH and FSH levels. It decreases the expression of unoccupied pituitary GnRH receptors, resulting in significant downregulation of gonadotropin beta-subunit mRNA in the pituitary gland. The modulatory effects of ORG 30276 on gonadotropin dynamics can be selectively reversed by the administration of specific sex steroids, particularly androgens, which notably influence FSH beta-subunit mRNA levels. This compound is valuable for research in reproductive biology and endocrine regulation.
Chemical Information
| Catalog Num | A60711 |
|---|---|
| M. Wt | 1453.47 |
| Formula | C69H91Cl2N17O14 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 83539-08-6 |
| Synonyms | APTAA-LHRH |
| SMILES | C([C@@H](NC([C@@H](CC1=CC=C(Cl)C=C1)NC([C@@H](CC2=CC=C(Cl)C=C2)NC(C)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@@H](C(O)=O)C)=O)CCC4)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)CO)=O)C=5C=6C(NC5)=CC=CC6 |
Biological Activity
| Description | ORG 30276 is a potent GnRH receptor antagonist that effectively inhibits gonadotropin secretion by reducing serum LH and FSH levels. It decreases the expression of unoccupied pituitary GnRH receptors, resulting in significant downregulation of gonadotropin beta-subunit mRNA in the pituitary gland. The modulatory effects of ORG 30276 on gonadotropin dynamics can be selectively reversed by the administration of specific sex steroids, particularly androgens, which notably influence FSH beta-subunit mRNA levels. This compound is valuable for research in reproductive biology and endocrine regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
