Product Data Sheet
Org-30850
Catalog No. A60745
Org-30850 is a potent GnRH receptor antagonist that effectively targets hormone-dependent disorders. Preclinical studies demonstrate its capability to inhibit ovulation in female rats and significantly lower testosterone levels in males for up to 48 hours following a single subcutaneous administration. Administration of daily doses in female rats resulted in suppression of estrous cycles and reduction of uterine and ovarian weights, accompanied by decreased estradiol and FSH serum levels. In male rats, prolonged treatment led to reversible declines in gonadal function and testosterone levels, with nearly complete recovery after treatment cessation. Org-30850 is characterized by minimal injection site irritation, indicating a potentially more favorable therapeutic profile.
Chemical Information
| Catalog Num | A60745 |
|---|---|
| M. Wt | 1441.53 |
| Formula | C69H91Cl2N15O13S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 136208-71-4 |
| Synonyms | Org 30850ANT |
| SMILES | C([C@@H](NC([C@@H](CC1=CC=C(Cl)C=C1)NC([C@@H](CC2=CC=C(Cl)C=C2)NC(C)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@@H](C(N)=O)C)=O)CCC4)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)=O)CO)=O)C=5C=6C(SC5)=CC=CC6 |
Biological Activity
| Description | Org-30850 is a potent GnRH receptor antagonist that effectively targets hormone-dependent disorders. Preclinical studies demonstrate its capability to inhibit ovulation in female rats and significantly lower testosterone levels in males for up to 48 hours following a single subcutaneous administration. Administration of daily doses in female rats resulted in suppression of estrous cycles and reduction of uterine and ovarian weights, accompanied by decreased estradiol and FSH serum levels. In male rats, prolonged treatment led to reversible declines in gonadal function and testosterone levels, with nearly complete recovery after treatment cessation. Org-30850 is characterized by minimal injection site irritation, indicating a potentially more favorable therapeutic profile. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
