Product Data Sheet
YH18968
Catalog No. A60776
YH18968 is an orally active GPR119 agonist, exhibiting an EC50 of 2.8 nM for cAMP accumulation. This compound enhances intracellular cyclic adenosine monophosphate levels, promotes glucagon-like peptide-1 secretion from intestinal L cells, and stimulates glucose-dependent insulin secretion from pancreatic β cells. YH18968 has been shown to improve glucose tolerance in both normal and diet-induced obese mouse models, making it a valuable reagent for research aimed at understanding and managing type 2 diabetes.
Chemical Information
| Catalog Num | A60776 |
|---|---|
| M. Wt | 545.58 |
| Formula | C27H28FN9O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1632498-56-6 |
| Synonyms | |
| SMILES | O=C1N(C=NN1[C@H]2CCOC2)C3=C(F)C=C(C=C3)C=4C=C(C#N)C(=NC4)N5CCN(CC5)C=6N=C(C(C)C)ON6 |
Biological Activity
| Description | YH18968 is an orally active GPR119 agonist, exhibiting an EC50 of 2.8 nM for cAMP accumulation. This compound enhances intracellular cyclic adenosine monophosphate levels, promotes glucagon-like peptide-1 secretion from intestinal L cells, and stimulates glucose-dependent insulin secretion from pancreatic β cells. YH18968 has been shown to improve glucose tolerance in both normal and diet-induced obese mouse models, making it a valuable reagent for research aimed at understanding and managing type 2 diabetes. |
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RETURN POLICY
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
