Product Data Sheet
MKP10241
Catalog No. A60777
MKP10241 is an orally active agonist of GPR119, a G protein-coupled receptor involved in the regulation of glucose metabolism. This compound significantly elevates cAMP levels in GPR119-expressing cell lines, demonstrating an EC50 of 3.7 nM. MKP10241 effectively lowers blood glucose levels and HbA1c in both acute and chronic diabetic mouse models, and exhibits promising preclinical efficacy in addressing obesity and metabolic associated steatotic hepatitis (MASH) in rodent studies.
Chemical Information
| Catalog Num | A60777 |
|---|---|
| M. Wt | 530.64 |
| Formula | C24H27FN6O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2137977-29-6 |
| Synonyms | |
| SMILES | C[C@@H](C1CCN(CC1)C2=NC=C(C=N2)CC)OC(S3)=NN4C3=NC(C5=CC=C(C=C5F)S(C)(=O)=O)=C4 |
Biological Activity
| Description | MKP10241 is an orally active agonist of GPR119, a G protein-coupled receptor involved in the regulation of glucose metabolism. This compound significantly elevates cAMP levels in GPR119-expressing cell lines, demonstrating an EC50 of 3.7 nM. MKP10241 effectively lowers blood glucose levels and HbA1c in both acute and chronic diabetic mouse models, and exhibits promising preclinical efficacy in addressing obesity and metabolic associated steatotic hepatitis (MASH) in rodent studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
