Product Data Sheet
Lithocholic acid 3-sulfate (disodium)
Catalog No. A60812
Lithocholic acid 3-sulfate (disodium) is a GPR39 agonist demonstrating robust activation with EC50 values of 0.88 μM in the presence of Zn2+ and 41 μM in its absence, in relevant cell lines. This compound initiates intracellular calcium signaling through GPR39, not relying on Zn2+-binding sites. Additionally, it functions as a ligand for RORγt, selectively inhibiting Th17 cell differentiation. Lithocholic acid 3-sulfate (disodium) is valuable for investigations into cholestatic liver diseases and related immunological studies.
Chemical Information
| Catalog Num | A60812 |
|---|---|
| M. Wt | 500.60 |
| Formula | C24H38Na2O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 64936-81-8 |
| Synonyms | Sulfolithocholic acid (disodium); LCAS (disodium) |
| SMILES | C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCC(O[Na])=O)([H])[C@@](CC[C@]3([H])C[C@@H]4O[S](=O)(O[Na])=O)([H])[C@@]2([H])[C@]3(CC4)C |
Biological Activity
| Description | Lithocholic acid 3-sulfate (disodium) is a GPR39 agonist demonstrating robust activation with EC50 values of 0.88 μM in the presence of Zn2+ and 41 μM in its absence, in relevant cell lines. This compound initiates intracellular calcium signaling through GPR39, not relying on Zn2+-binding sites. Additionally, it functions as a ligand for RORγt, selectively inhibiting Th17 cell differentiation. Lithocholic acid 3-sulfate (disodium) is valuable for investigations into cholestatic liver diseases and related immunological studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
