Product Data Sheet
Taurolithocholic acid 3-sulfate disodium
Catalog No. A60813
Taurolithocholic acid 3-sulfate disodium is an agonist of the GPR39 receptor, demonstrating EC50 values of 71.6 μM and 69.4 μM in the absence of Zn2+ and 9 μM and 9.6 μM in the presence of Zn2+, as observed in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 to promote intracellular calcium signaling while functioning independently of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium is suitable for investigations related to gallbladder disease and its underlying mechanisms.
Chemical Information
| Catalog Num | A60813 |
|---|---|
| M. Wt | 607.73 |
| Formula | C26H43NNa2O8S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 64936-83-0 |
| Synonyms | 3-Sulfotaurolithocholic acid disodium |
| SMILES | C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
Biological Activity
| Description | Taurolithocholic acid 3-sulfate disodium is an agonist of the GPR39 receptor, demonstrating EC50 values of 71.6 μM and 69.4 μM in the absence of Zn2+ and 9 μM and 9.6 μM in the presence of Zn2+, as observed in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 to promote intracellular calcium signaling while functioning independently of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium is suitable for investigations related to gallbladder disease and its underlying mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
