Product Data Sheet
NXE0041178
Catalog No. A60816
NXE0041178 is a potent full agonist of the GPR52 receptor, exhibiting a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM for rat GPR52. This compound demonstrates an ability to penetrate the blood-brain barrier and shows minimal inhibition of hERG, hNaV1.5, and cytochrome P450 isoforms. Notably, NXE0041178 effectively reduces d-amphetamine-induced hyperactivity in rat models, making it a valuable tool for research related to neurological disorders.
Chemical Information
| Catalog Num | A60816 |
|---|---|
| M. Wt | 390.33 |
| Formula | C19H14F4N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2642079-89-6 |
| Synonyms | |
| SMILES | O=C1NCCC2=C1C=NN2C3=CC(CC4=CC(F)=CC(C(F)(F)F)=C4)=NC=C3 |
Biological Activity
| Description | NXE0041178 is a potent full agonist of the GPR52 receptor, exhibiting a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM for rat GPR52. This compound demonstrates an ability to penetrate the blood-brain barrier and shows minimal inhibition of hERG, hNaV1.5, and cytochrome P450 isoforms. Notably, NXE0041178 effectively reduces d-amphetamine-induced hyperactivity in rat models, making it a valuable tool for research related to neurological disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
