Product Data Sheet
MCUF-651
Catalog No. A60865
MCUF-651 is a positive allosteric modulator of the guanylyl cyclase A receptor (GC-A), exhibiting a binding affinity (KD) of 397 nM. This compound selectively enhances the interaction of atrial natriuretic peptide (ANP) with GC-A, leading to increased cGMP production in human cardiac, renal, and adipose tissues. Additionally, MCUF-651 demonstrates the ability to inhibit cardiomyocyte hypertrophy, making it a valuable tool for research in cardiovascular and metabolic pathways.
Chemical Information
| Catalog Num | A60865 |
|---|---|
| M. Wt | 368.44 |
| Formula | C17H22F2N4OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2747162-85-0 |
| Synonyms | |
| SMILES | O=C(C1CN(CCC1)CCN(C)C)NC2=NC3=C(S2)C=C(F)C=C3F |
Biological Activity
| Description | MCUF-651 is a positive allosteric modulator of the guanylyl cyclase A receptor (GC-A), exhibiting a binding affinity (KD) of 397 nM. This compound selectively enhances the interaction of atrial natriuretic peptide (ANP) with GC-A, leading to increased cGMP production in human cardiac, renal, and adipose tissues. Additionally, MCUF-651 demonstrates the ability to inhibit cardiomyocyte hypertrophy, making it a valuable tool for research in cardiovascular and metabolic pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
