Product Data Sheet
S-3448
Catalog No. A60887
S-3448 is a soluble guanylate cyclase (sGC) agonist that selectively activates both the heme-containing and heme-deficient forms of sGC, independent of nitric oxide and heme. This compound demonstrates significant biological activity in modulating intracellular signaling pathways related to vasodilation and cardiovascular function. S-3448 is valuable for research applications focused on cardiovascular diseases, including arterial hypertension and pulmonary hypertension, providing insights into potential therapeutic strategies.
Chemical Information
| Catalog Num | A60887 |
|---|---|
| M. Wt | 612.14 |
| Formula | C25H26ClN3O7S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 254877-04-8 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(S(=O)(N2CCSCC2)=O)C=C1)C3=CC(OC)=C(OC)C=C3NS(=O)(C4=CC=C(Cl)C=C4)=O |
Biological Activity
| Description | S-3448 is a soluble guanylate cyclase (sGC) agonist that selectively activates both the heme-containing and heme-deficient forms of sGC, independent of nitric oxide and heme. This compound demonstrates significant biological activity in modulating intracellular signaling pathways related to vasodilation and cardiovascular function. S-3448 is valuable for research applications focused on cardiovascular diseases, including arterial hypertension and pulmonary hypertension, providing insights into potential therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
