Product Data Sheet
GPR81 agonist 1
Catalog No. A60900
GPR81 agonist 1 is a selective agonist targeting the GPR81 receptor, demonstrating EC50 values of 58 nM for human GPR81 and 50 nM for mouse GPR81. This compound effectively inhibits lipolysis in differentiated 3T3-L1 adipocytes and demonstrates an ability to suppress lipolysis in vivo in mouse models without causing cutaneous flushing. GPR81 agonist 1 exhibits significant selectivity for GPR81 over GPR109a, making it a valuable tool for research into metabolic regulation and adipocyte biology.
Chemical Information
| Catalog Num | A60900 |
|---|---|
| M. Wt | 446.63 |
| Formula | C22H30N4O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1620992-67-7 |
| Synonyms | |
| SMILES | O=C([C@H]1CC[C@H](C)CC1)NC2=NC(C3=CC=CS3)=C(CC(N4CCN(C)CC4)=O)S2 |
Biological Activity
| Description | GPR81 agonist 1 is a selective agonist targeting the GPR81 receptor, demonstrating EC50 values of 58 nM for human GPR81 and 50 nM for mouse GPR81. This compound effectively inhibits lipolysis in differentiated 3T3-L1 adipocytes and demonstrates an ability to suppress lipolysis in vivo in mouse models without causing cutaneous flushing. GPR81 agonist 1 exhibits significant selectivity for GPR81 over GPR109a, making it a valuable tool for research into metabolic regulation and adipocyte biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
