Product Data Sheet
ICMT-IN-53
Catalog No. A60946
ICMT-IN-53 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.96 μM. This compound demonstrates significant antiproliferative activity, effectively inhibiting the growth of MDA-MB-231 and PC3 cancer cell lines with IC50 values of 5.14 μM and 5.88 μM, respectively. ICMT-IN-53's PAMPA permeability makes it suitable for various biological research applications, particularly in the study of cancer cell proliferation and signaling pathways.
Chemical Information
| Catalog Num | A60946 |
|---|---|
| M. Wt | 409.58 |
| Formula | C26H36FN3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1443253-17-5 |
| Synonyms | |
| SMILES | FC1=C(C=CN=C1)C2=CC=C(N(CCCCCCCC)C=C3CN(CC)CC)C3=C2 |
Biological Activity
| Description | ICMT-IN-53 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.96 μM. This compound demonstrates significant antiproliferative activity, effectively inhibiting the growth of MDA-MB-231 and PC3 cancer cell lines with IC50 values of 5.14 μM and 5.88 μM, respectively. ICMT-IN-53's PAMPA permeability makes it suitable for various biological research applications, particularly in the study of cancer cell proliferation and signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
