Product Data Sheet
TAK-683
Catalog No. A60972
TAK-683 is a potent full agonist of the KISS1 receptor (KISS1R), exhibiting an IC50 value of 170 pM and a remarkable metabolic stability. As a nonapeptide analog of metastin, TAK-683 demonstrates significant agonistic activity with EC50 values of 0.96 nM and 1.6 nM for human and rat KISS1R, respectively. This compound effectively depletes GnRH in the hypothalamus and subsequently lowers plasma levels of FSH, LH, and testosterone. TAK-683 is valuable for investigating hormone-dependent prostate cancer and related endocrine research applications.
Chemical Information
| Catalog Num | A60972 |
|---|---|
| M. Wt | 1298.45 |
| Formula | C64H83N17O13 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 872719-49-8 |
| Synonyms | |
| SMILES | C([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(NNC(N[C@H](C(N[C@H](C(N[C@@H](CC=3C=4C(NC3)=CC=CC4)C(N)=O)=O)CCCNC(NC)=N)=O)CC(C)C)=O)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)C=5C=6C(NC5)=CC=CC6 |
Biological Activity
| Description | TAK-683 is a potent full agonist of the KISS1 receptor (KISS1R), exhibiting an IC50 value of 170 pM and a remarkable metabolic stability. As a nonapeptide analog of metastin, TAK-683 demonstrates significant agonistic activity with EC50 values of 0.96 nM and 1.6 nM for human and rat KISS1R, respectively. This compound effectively depletes GnRH in the hypothalamus and subsequently lowers plasma levels of FSH, LH, and testosterone. TAK-683 is valuable for investigating hormone-dependent prostate cancer and related endocrine research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
