Product Data Sheet
ZPL-5212372
Catalog No. A61018
ZPL-5212372 is a potent inhibitor of cytosolic phospholipase A2 alpha (cPLA2α) with an IC50 of 7 nM. This compound efficiently reduces the release of key inflammatory mediators such as prostaglandin D2, cysteinyl leukotrienes, leukotriene B4, and thromboxane A2 from human lung cells. Research indicates that ZPL-5212372 effectively attenuates delayed bronchoconstriction and airway hyperresponsiveness in models of allergic inflammation. Consequently, it serves as a valuable tool for investigating mechanisms and potential therapies for asthma.
Chemical Information
| Catalog Num | A61018 |
|---|---|
| M. Wt | 823.34 |
| Formula | C42H38ClF3N2O6S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 916136-25-9 |
| Synonyms | PF 5212372 |
| SMILES | O=C(O)CCC1=CC=C(S(=O)(CCC2=C(CCNS(=O)(CC3=CC=CC=C3C(F)(F)F)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)=O)C=C1 |
Biological Activity
| Description | ZPL-5212372 is a potent inhibitor of cytosolic phospholipase A2 alpha (cPLA2α) with an IC50 of 7 nM. This compound efficiently reduces the release of key inflammatory mediators such as prostaglandin D2, cysteinyl leukotrienes, leukotriene B4, and thromboxane A2 from human lung cells. Research indicates that ZPL-5212372 effectively attenuates delayed bronchoconstriction and airway hyperresponsiveness in models of allergic inflammation. Consequently, it serves as a valuable tool for investigating mechanisms and potential therapies for asthma. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
