Product Data Sheet
CP-288886
Catalog No. A61028
CP-288886 is a potent cysLT1 receptor antagonist, demonstrating a Ki value of 0.004 μM. It effectively inhibits calcium mobilization in human U937 cells, with an IC50 of 0.0005 μM. This compound exhibits promising anti-asthmatic activity in preclinical models, such as the guinea pig asthma model, making it a valuable tool for researching respiratory diseases, particularly asthma. Its high oral bioavailability further supports its potential for in vivo studies.
Chemical Information
| Catalog Num | A61028 |
|---|---|
| M. Wt | 637.07 |
| Formula | C30H28ClF3N2O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 221332-74-7 |
| Synonyms | |
| SMILES | O[C@H]1C2=CC(OCC3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2OC(C)(C)[C@H]1CC5=C(C=CC(NS(C(F)(F)F)(=O)=O)=C5)OC |
Biological Activity
| Description | CP-288886 is a potent cysLT1 receptor antagonist, demonstrating a Ki value of 0.004 μM. It effectively inhibits calcium mobilization in human U937 cells, with an IC50 of 0.0005 μM. This compound exhibits promising anti-asthmatic activity in preclinical models, such as the guinea pig asthma model, making it a valuable tool for researching respiratory diseases, particularly asthma. Its high oral bioavailability further supports its potential for in vivo studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
