Product Data Sheet
LY 163443
Catalog No. A61031
LY 163443 is a selective antagonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4), exhibiting significant inhibitory effects on LTD4 and LTE4-mediated biological activities. This compound effectively antagonizes LTD4-induced contractions in guinea pig ileum, trachea, and lung parenchyma, as well as inhibiting tracheal contractions elicited by LTE4. Its application in research includes studying the role of leukotrienes in airway hyperreactivity and potential therapeutic interventions in respiratory conditions.
Chemical Information
| Catalog Num | A61031 |
|---|---|
| M. Wt | 366.41 |
| Formula | C20H22N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 97581-70-9 |
| Synonyms | |
| SMILES | CC(C1=CC=C(C(CCC)=C1O)COC2=CC=C(C=C2)CC3=NN=NN3)=O |
Biological Activity
| Description | LY 163443 is a selective antagonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4), exhibiting significant inhibitory effects on LTD4 and LTE4-mediated biological activities. This compound effectively antagonizes LTD4-induced contractions in guinea pig ileum, trachea, and lung parenchyma, as well as inhibiting tracheal contractions elicited by LTE4. Its application in research includes studying the role of leukotrienes in airway hyperreactivity and potential therapeutic interventions in respiratory conditions. |
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RETURN POLICY
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
