Product Data Sheet
Leukotriene B5
Catalog No. A61045
Leukotriene B5 (LTB5) is a leukotriene receptor activator, primarily influencing inflammatory responses. As a metabolite of eicosapentaenoic acid produced via the 5-lipoxygenase (5-LO) pathway, LTB5 is known to increase the contraction of bullfrog lung strips in a concentration-dependent manner. In vivo studies demonstrate that LTB5 (100 nM) can significantly reduce tumor volume in mice with Tm1 murine melanoma cells. Additionally, LTB5 induces chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes at significantly lower levels compared to LTB4, and exhibits reduced platelet aggregation.
Chemical Information
| Catalog Num | A61045 |
|---|---|
| M. Wt | 334.45 |
| Formula | C20H30O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 80445-66-5 |
| Synonyms | LTB5 |
| SMILES | CC/C=C\C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O |
Biological Activity
| Description | Leukotriene B5 (LTB5) is a leukotriene receptor activator, primarily influencing inflammatory responses. As a metabolite of eicosapentaenoic acid produced via the 5-lipoxygenase (5-LO) pathway, LTB5 is known to increase the contraction of bullfrog lung strips in a concentration-dependent manner. In vivo studies demonstrate that LTB5 (100 nM) can significantly reduce tumor volume in mice with Tm1 murine melanoma cells. Additionally, LTB5 induces chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes at significantly lower levels compared to LTB4, and exhibits reduced platelet aggregation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
