Product Data Sheet
YM-16638
Catalog No. A61052
YM-16638 is a potent orally active leukotriene antagonist targeting leukotrienes C4, D4, and E4. It effectively inhibits their production in guinea pig trachea with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. Additionally, YM-16638 demonstrates a dose-dependent inhibitory effect on both early and late antigen-induced respiratory responses in allergic sheep, making it a valuable tool for research in respiratory and allergic conditions.
Chemical Information
| Catalog Num | A61052 |
|---|---|
| M. Wt | 442.57 |
| Formula | C18H22N2O5S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 104073-72-5 |
| Synonyms | YM 638 |
| SMILES | O=C(O)CSC1=NN=C(SCCCOC2=CC=C(C(C)=O)C(O)=C2CCC)S1 |
Biological Activity
| Description | YM-16638 is a potent orally active leukotriene antagonist targeting leukotrienes C4, D4, and E4. It effectively inhibits their production in guinea pig trachea with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. Additionally, YM-16638 demonstrates a dose-dependent inhibitory effect on both early and late antigen-induced respiratory responses in allergic sheep, making it a valuable tool for research in respiratory and allergic conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
