Product Data Sheet
SR2640
Catalog No. A61053
SR2640 is a potent and selective antagonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4). It effectively inhibits LTD4-induced smooth muscle contractions in the guinea pig ileum and trachea without interfering with histamine-induced contractions. At a concentration of 23 nM, SR2640 prevents the binding of [3H] LTD4 to receptors in guinea pig lung tissue, demonstrating its high affinity. This compound is suitable for research applications related to asthma and bronchoconstriction, as it shifts the dose-response curve for LTD4-induced bronchoconstriction in guinea pigs to the right, correlating with the administered dose of SR2640.
Chemical Information
| Catalog Num | A61053 |
|---|---|
| M. Wt | 370.40 |
| Formula | C23H18N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 105350-26-3 |
| Synonyms | QMPB |
| SMILES | O=C(O)C1=CC=CC=C1NC2=CC=CC(OCC3=NC4=CC=CC=C4C=C3)=C2 |
Biological Activity
| Description | SR2640 is a potent and selective antagonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4). It effectively inhibits LTD4-induced smooth muscle contractions in the guinea pig ileum and trachea without interfering with histamine-induced contractions. At a concentration of 23 nM, SR2640 prevents the binding of [3H] LTD4 to receptors in guinea pig lung tissue, demonstrating its high affinity. This compound is suitable for research applications related to asthma and bronchoconstriction, as it shifts the dose-response curve for LTD4-induced bronchoconstriction in guinea pigs to the right, correlating with the administered dose of SR2640. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
