Product Data Sheet
SB 201146
Catalog No. A61087
SB 201146 is a potent leukotriene B4 (LTB4) receptor antagonist, exhibiting activity in the range of 10 pM to 1 μM. Its primary mechanism involves the modulation of eosinophil survival, which is a critical factor in asthma-related airway inflammation. Research indicates that SB 201146 can effectively reverse the eosinophil survival promoted by mast cells and lymphocytes, suggesting its therapeutic potential in disrupting the autocrine cysteinyl leukotriene pathway. Furthermore, this compound underscores the role of LTB4 as a paracrine mediator, influencing eosinophil dynamics in various inflammatory conditions, particularly asthma.
Chemical Information
| Catalog Num | A61087 |
|---|---|
| M. Wt | 542.62 |
| Formula | C30H35LiN2O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 141311-11-7 |
| Synonyms | |
| SMILES | O=C(O[Li])/C=C/C1=NC(CS(C2=CC=CC(N)=C2)=O)=CC=C1OCCCCCCCCC3=CC=C(OC)C=C3 |
Biological Activity
| Description | SB 201146 is a potent leukotriene B4 (LTB4) receptor antagonist, exhibiting activity in the range of 10 pM to 1 μM. Its primary mechanism involves the modulation of eosinophil survival, which is a critical factor in asthma-related airway inflammation. Research indicates that SB 201146 can effectively reverse the eosinophil survival promoted by mast cells and lymphocytes, suggesting its therapeutic potential in disrupting the autocrine cysteinyl leukotriene pathway. Furthermore, this compound underscores the role of LTB4 as a paracrine mediator, influencing eosinophil dynamics in various inflammatory conditions, particularly asthma. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
