Product Data Sheet
AMG 369
Catalog No. A61212
AMG 369 is a potent, orally bioavailable dual agonist of the sphingosine-1-phosphate receptors S1P1 and S1P5, with minimal activity at S1P3 and no affinity for S1P2 or S1P4. This compound effectively reduces blood lymphocyte counts, demonstrating its immunomodulatory effects. AMG 369 has been shown to delay the onset and diminish the severity of experimental autoimmune encephalomyelitis in rat models, making it a valuable tool for research into autoimmune diseases and inflammatory responses.
Chemical Information
| Catalog Num | A61212 |
|---|---|
| M. Wt | 459.54 |
| Formula | C26H22FN3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1202073-26-4 |
| Synonyms | |
| SMILES | O=C(O)C1CN(CC2=CC=C(C(F)=C2)C3=NC=4C=CC(=NC4S3)C5(C=6C=CC=CC6)CC5)C1 |
Biological Activity
| Description | AMG 369 is a potent, orally bioavailable dual agonist of the sphingosine-1-phosphate receptors S1P1 and S1P5, with minimal activity at S1P3 and no affinity for S1P2 or S1P4. This compound effectively reduces blood lymphocyte counts, demonstrating its immunomodulatory effects. AMG 369 has been shown to delay the onset and diminish the severity of experimental autoimmune encephalomyelitis in rat models, making it a valuable tool for research into autoimmune diseases and inflammatory responses. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
