Product Data Sheet
1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA
Catalog No. A61247
1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid that features arachidonic acid at the sn-1 position and serves as a precursor to 1-arachidonoyl glycerol. This compound exhibits potent binding to the LPA2/EDG4 receptor, with an EC50 value of approximately 10 nM. Its biological activity includes the inhibition of TNF-α and IL-6 secretion in wild-type dendritic cells activated by LPS, as well as the reduction of HT-29 human colon carcinoma cell differentiation into goblet cells upon sodium butyrate treatment. This makes it a valuable tool for studying inflammation and cancer biology.
Chemical Information
| Catalog Num | A61247 |
|---|---|
| M. Wt | 458.53 |
| Formula | C23H39O7P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 65446-08-4 |
| Synonyms | 1-Arachidonoyl-sn-glycerol 3-phosphate; 1-Arachidonoyl LPA; LPA (20:4) |
| SMILES | O=P(O)(O)OC[C@H](O)COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O |
Biological Activity
| Description | 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid that features arachidonic acid at the sn-1 position and serves as a precursor to 1-arachidonoyl glycerol. This compound exhibits potent binding to the LPA2/EDG4 receptor, with an EC50 value of approximately 10 nM. Its biological activity includes the inhibition of TNF-α and IL-6 secretion in wild-type dendritic cells activated by LPS, as well as the reduction of HT-29 human colon carcinoma cell differentiation into goblet cells upon sodium butyrate treatment. This makes it a valuable tool for studying inflammation and cancer biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
