Product Data Sheet
McN-A-343
Catalog No. A61287
McN-A-343 is a selective M1 muscarinic agonist that enhances muscarinic transmission in sympathetic ganglia. This compound significantly inhibits muscarine-induced catecholamine secretion in isolated perfused rat adrenal glands and plays a role in neuronal firing regulation. Additionally, McN-A-343 activates enteroendocrine L cells to promote the release of glucagon-like peptide 1 (GLP-1) and modulates α-melanocyte stimulating hormone (α-MSH) secretion from the pituitary gland. Its capacity to reduce colonic inflammation and oxidative stress makes McN-A-343 a valuable tool for studying ulcerative colitis.
Chemical Information
| Catalog Num | A61287 |
|---|---|
| M. Wt | 317.21 |
| Formula | C14H18Cl2N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 55-45-8 |
| Synonyms | |
| SMILES | O=C(NC1=CC(Cl)=CC=C1)OCC#CC[N+](C)(C)C.[Cl-] |
Biological Activity
| Description | McN-A-343 is a selective M1 muscarinic agonist that enhances muscarinic transmission in sympathetic ganglia. This compound significantly inhibits muscarine-induced catecholamine secretion in isolated perfused rat adrenal glands and plays a role in neuronal firing regulation. Additionally, McN-A-343 activates enteroendocrine L cells to promote the release of glucagon-like peptide 1 (GLP-1) and modulates α-melanocyte stimulating hormone (α-MSH) secretion from the pituitary gland. Its capacity to reduce colonic inflammation and oxidative stress makes McN-A-343 a valuable tool for studying ulcerative colitis. |
|---|
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
