Product Data Sheet
MRGPRX1 agonist 1
Catalog No. A61575
MRGPRX1 agonist 1 is a potent agonist of the Mas-related G protein-coupled receptor X1 (MRGPRX1), demonstrating an EC50 of 50 nM and over 50-fold selectivity against δ, μ, and κ opioid receptors. This compound is ineffective against MRGPRC11, which plays a role in inhibiting high voltage-activated (HVA) Ca2+ currents, thereby reducing neurotransmitter release and influencing nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is valuable for investigating mechanisms of chronic pain, particularly neuropathic pain, facilitating research into potential therapeutic strategies.
Chemical Information
| Catalog Num | A61575 |
|---|---|
| M. Wt | 435.50 |
| Formula | C23H21N3O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2377379-39-8 |
| Synonyms | |
| SMILES | O=S(C1=CC=CC=C1OC)(NC2=CC=C(C)C=C2OC3=CC4=C(C(N)=NC=C4)C=C3)=O |
Biological Activity
| Description | MRGPRX1 agonist 1 is a potent agonist of the Mas-related G protein-coupled receptor X1 (MRGPRX1), demonstrating an EC50 of 50 nM and over 50-fold selectivity against δ, μ, and κ opioid receptors. This compound is ineffective against MRGPRC11, which plays a role in inhibiting high voltage-activated (HVA) Ca2+ currents, thereby reducing neurotransmitter release and influencing nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is valuable for investigating mechanisms of chronic pain, particularly neuropathic pain, facilitating research into potential therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
