Product Data Sheet
MRGPRX1 agonist 4
Catalog No. A61584
MRGPRX1 agonist 4 is a potent positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGPRX1), exhibiting an EC50 value of 0.1 μM. This compound demonstrates favorable metabolic stability and oral bioavailability. MRGPRX1 agonist 4 has been shown to alleviate behavioral heat hypersensitivity in humanized MRGPRX1 mice models of neuropathic pain, making it a valuable tool for research in pain modulation and related therapeutic applications.
Chemical Information
| Catalog Num | A61584 |
|---|---|
| M. Wt | 513.36 |
| Formula | C23H17Cl2F3N2O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2764889-60-1 |
| Synonyms | |
| SMILES | CC(C)(C1=C(C2=CC=C(C(Cl)=C2)Cl)C3=C(N=CN=C3OC4=C(C=CC=C4)OC(F)(F)F)S1)C |
Biological Activity
| Description | MRGPRX1 agonist 4 is a potent positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGPRX1), exhibiting an EC50 value of 0.1 μM. This compound demonstrates favorable metabolic stability and oral bioavailability. MRGPRX1 agonist 4 has been shown to alleviate behavioral heat hypersensitivity in humanized MRGPRX1 mice models of neuropathic pain, making it a valuable tool for research in pain modulation and related therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
