Product Data Sheet
Dersimelagon
Catalog No. A61629
Dersimelagon is a selective agonist of the melanocortin 1 receptor (MC1R) with demonstrated efficacy in human (EC50 of 8.16 nM), cynomolgus monkey (3.91 nM), mouse (1.14 nM), and rat (0.251 nM) models. It exhibits strong binding affinity for hMC1R and hMC4R, with Ki values of 2.26 nM and 32.9 nM, respectively. This compound is primarily utilized in research focused on skin pigmentation and the modulation of melanin synthesis.
Chemical Information
| Catalog Num | A61629 |
|---|---|
| M. Wt | 675.75 |
| Formula | C36H45F4N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1835256-48-8 |
| Synonyms | MT-7117 |
| SMILES | O=C(N1C[C@H](C2=C(N3CCC(C(O)=O)CC3)C=C(C(F)(F)F)C=C2)[C@@H](COC)C1)[C@]4([C@H](C5=CC=C(OC)C=C5)CN(C6CCCC6)C4)F |
Biological Activity
| Description | Dersimelagon is a selective agonist of the melanocortin 1 receptor (MC1R) with demonstrated efficacy in human (EC50 of 8.16 nM), cynomolgus monkey (3.91 nM), mouse (1.14 nM), and rat (0.251 nM) models. It exhibits strong binding affinity for hMC1R and hMC4R, with Ki values of 2.26 nM and 32.9 nM, respectively. This compound is primarily utilized in research focused on skin pigmentation and the modulation of melanin synthesis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
