Product Data Sheet
HS014
Catalog No. A61677
HS014 is a selective antagonist of the melanocortin-4 (MC4) receptor, exhibiting a Ki of 3.16 nM for human MC4, while demonstrating significantly lower affinities for MC1, MC3, and MC5 receptors. This compound has been shown to modulate morphine-induced behaviors in murine models, as well as to facilitate increased food intake in free-feeding rat studies. HS014 is a valuable tool in research exploring the regulation of appetite and pain modulation.
Chemical Information
| Catalog Num | A61677 |
|---|---|
| M. Wt | 1563.76 |
| Formula | C71H94N20O17S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 207678-81-7 |
| Synonyms | |
| SMILES | C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(=O)N7[C@H](C(=O)N8[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N)=O)=O)CCCCN)=O)CCC8)CCC7)NC(=O)CNC3=O |
Biological Activity
| Description | HS014 is a selective antagonist of the melanocortin-4 (MC4) receptor, exhibiting a Ki of 3.16 nM for human MC4, while demonstrating significantly lower affinities for MC1, MC3, and MC5 receptors. This compound has been shown to modulate morphine-induced behaviors in murine models, as well as to facilitate increased food intake in free-feeding rat studies. HS014 is a valuable tool in research exploring the regulation of appetite and pain modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
