Product Data Sheet
BMS-470539
Catalog No. A61682
BMS-470539 is a synthetic agonist of the melanocortin-1 receptor (MC-1R), notable for its potent anti-inflammatory properties. With EC50 values of 16.8 nM and 11.6 nM for human and murine MC-1R activation respectively, it effectively inhibits TNF-alpha-induced NF-kB activation in human melanoma cells. In vivo studies demonstrate that subcutaneous administration of BMS-470539 in BALB/c mice significantly reduces LPS-induced TNF-alpha production, leukocyte infiltration in lung inflammation, and paw swelling in delayed-type hypersensitivity models, indicating its potential as a therapeutic agent targeting inflammation through MC-1R modulation.
Chemical Information
| Catalog Num | A61682 |
|---|---|
| M. Wt | 559.70 |
| Formula | C32H41N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 457893-92-4 |
| Synonyms | |
| SMILES | CCCC(C1(C2=CC=CC=C2)CCN(C([C@@H](CC3=CC=C(C=C3)OC)NC([C@H](CC4=CN=CN4C)N)=O)=O)CC1)=O |
Biological Activity
| Description | BMS-470539 is a synthetic agonist of the melanocortin-1 receptor (MC-1R), notable for its potent anti-inflammatory properties. With EC50 values of 16.8 nM and 11.6 nM for human and murine MC-1R activation respectively, it effectively inhibits TNF-alpha-induced NF-kB activation in human melanoma cells. In vivo studies demonstrate that subcutaneous administration of BMS-470539 in BALB/c mice significantly reduces LPS-induced TNF-alpha production, leukocyte infiltration in lung inflammation, and paw swelling in delayed-type hypersensitivity models, indicating its potential as a therapeutic agent targeting inflammation through MC-1R modulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
