Product Data Sheet
RO27-3225
Catalog No. A61694
RO27-3225 is a potent and selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating a 30-fold selectivity for MC4R over MC3R. This compound shows significant neuroprotective and anti-inflammatory effects, making it valuable for research in metabolic disorders, obesity, and neurodegenerative diseases. Its specific action on MC4R positions RO27-3225 as a key reagent for exploring the therapeutic potential of melanocortin signaling pathways.
Chemical Information
| Catalog Num | A61694 |
|---|---|
| M. Wt | 784.91 |
| Formula | C39H52N12O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 274682-89-2 |
| Synonyms | |
| SMILES | C([C@H](NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC(CCC)=O)=O)=O)CCCNC(=N)N)=O)C(N(CC(N)=O)C)=O)C=3C=4C(NC3)=CC=CC4 |
Biological Activity
| Description | RO27-3225 is a potent and selective agonist of the melanocortin 4 receptor (MC4R), exhibiting an EC50 of 1 nM for MC4R and 8 nM for MC1R, demonstrating a 30-fold selectivity for MC4R over MC3R. This compound shows significant neuroprotective and anti-inflammatory effects, making it valuable for research in metabolic disorders, obesity, and neurodegenerative diseases. Its specific action on MC4R positions RO27-3225 as a key reagent for exploring the therapeutic potential of melanocortin signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
