Product Data Sheet
MK-0489
Catalog No. A61702
MK-0489 is a selective agonist targeting the melanocortin-4 receptor (MC4R). Demonstrating a strong binding affinity with an IC50 of 13 nM and functional activity characterized by an EC50 of 4.6 nM in human MC4R, it also exhibits an EC50 of 22 nM for mouse MC4R and 1.7 μM for mouse MC3R. This compound is valuable for research applications focused on obesity and related metabolic disorders.
Chemical Information
| Catalog Num | A61702 |
|---|---|
| M. Wt | 600.18 |
| Formula | C34H44ClF2N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 778625-65-3 |
| Synonyms | |
| SMILES | CC(NC(C)([C@@H]1CC2(CCN(C([C@@H]3CN(C(C)(C)C)C[C@H]3C4=CC=C(F)C=C4F)=O)CC2)C5=C1C=C(C)C(Cl)=C5)C)=O |
Biological Activity
| Description | MK-0489 is a selective agonist targeting the melanocortin-4 receptor (MC4R). Demonstrating a strong binding affinity with an IC50 of 13 nM and functional activity characterized by an EC50 of 4.6 nM in human MC4R, it also exhibits an EC50 of 22 nM for mouse MC4R and 1.7 μM for mouse MC3R. This compound is valuable for research applications focused on obesity and related metabolic disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
