Product Data Sheet
Bivamelagon hydrochloride
Catalog No. A61705
Bivamelagon hydrochloride is a potent agonist of the melanocortin 4 receptor (MC4R), demonstrating EC50 values of 0.562 nM in luciferase assays and 36.5 nM in cAMP assays, along with a Ki of 65 nM. This compound exhibits oral bioavailability and the ability to cross the blood-brain barrier, making it a valuable tool in research focused on metabolic disorders, particularly obesity and diabetes. Bivamelagon hydrochloride facilitates the exploration of MC4R signaling pathways and their implications in metabolic regulation.
Chemical Information
| Catalog Num | A61705 |
|---|---|
| M. Wt | 665.73 |
| Formula | C35H54Cl2N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2641595-55-1 |
| Synonyms | MC-4R Agonist 2 hydrochloride |
| SMILES | O=C([C@H]1[C@H](C2=CC=C(C=C2)Cl)CN(C1)C(C)(C)C)N3[C@@H](C[C@@H](C3)N([C@@H]4CC[C@@H](CC4)C)C(C(C)C)=O)C(N5CCOCC5)=O.[H]Cl |
Biological Activity
| Description | Bivamelagon hydrochloride is a potent agonist of the melanocortin 4 receptor (MC4R), demonstrating EC50 values of 0.562 nM in luciferase assays and 36.5 nM in cAMP assays, along with a Ki of 65 nM. This compound exhibits oral bioavailability and the ability to cross the blood-brain barrier, making it a valuable tool in research focused on metabolic disorders, particularly obesity and diabetes. Bivamelagon hydrochloride facilitates the exploration of MC4R signaling pathways and their implications in metabolic regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
