Product Data Sheet
4-P-PDOT
Catalog No. A61715
4-P-PDOT is a highly selective antagonist of the Melatonin MT2 receptor, exhibiting over 300-fold greater affinity for MT2 compared to the MT1 receptor. This compound effectively inhibits melatonin-induced antioxidant activities, as evidenced by its impact on the GSH/GSSG ratio, phospho-ERK levels, Nrf2 nuclear translocation, and Nrf2 DNA-binding activity. 4-P-PDOT is a valuable tool for research into melatonin signaling pathways and oxidative stress responses.
Chemical Information
| Catalog Num | A61715 |
|---|---|
| M. Wt | 279.38 |
| Formula | C19H21NO |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 134865-74-0 |
| Synonyms | |
| SMILES | CCC(NC1CC2=C(C=CC=C2)C(C3=CC=CC=C3)C1)=O |
Biological Activity
| Description | 4-P-PDOT is a highly selective antagonist of the Melatonin MT2 receptor, exhibiting over 300-fold greater affinity for MT2 compared to the MT1 receptor. This compound effectively inhibits melatonin-induced antioxidant activities, as evidenced by its impact on the GSH/GSSG ratio, phospho-ERK levels, Nrf2 nuclear translocation, and Nrf2 DNA-binding activity. 4-P-PDOT is a valuable tool for research into melatonin signaling pathways and oxidative stress responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
