Product Data Sheet
S-22153
Catalog No. A61718
S-22153 is a selective antagonist of the melatonin receptors MT1 and MT2, exhibiting high potency with EC50 values of 19 nM and 4.6 nM for hMT1 and hMT2, respectively. Its Ki values demonstrate strong binding affinity, measuring 8.6 nM for hMT1 in CHO cells and 16.3 nM in HEK cells, while exhibiting Ki values of 6.0 nM and 8.2 nM for hMT2 in the same cell lines. S-22153 is primarily utilized in research focusing on sleep regulation, circadian biology, and neuropharmacology.
Chemical Information
| Catalog Num | A61718 |
|---|---|
| M. Wt | 247.36 |
| Formula | C14H17NOS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 180304-07-8 |
| Synonyms | |
| SMILES | CC(NCCC1=CSC2=CC=C(C=C12)CC)=O |
Biological Activity
| Description | S-22153 is a selective antagonist of the melatonin receptors MT1 and MT2, exhibiting high potency with EC50 values of 19 nM and 4.6 nM for hMT1 and hMT2, respectively. Its Ki values demonstrate strong binding affinity, measuring 8.6 nM for hMT1 in CHO cells and 16.3 nM in HEK cells, while exhibiting Ki values of 6.0 nM and 8.2 nM for hMT2 in the same cell lines. S-22153 is primarily utilized in research focusing on sleep regulation, circadian biology, and neuropharmacology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
